CD30/TNFRSF8 Fc Chimera Protein, Mouse
SKU: 50353089028

CD30/TNFRSF8 Fc Chimera Protein, Mouse

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Description

CD30/TNFRSF8 Fc Chimera Protein, MouseProduct Specification Species Mouse Synonyms CD30; CD30KI 1; CD30L receptor; D1S166EKi 1; TNFRSF8 Accession Q60846 Amino Acid Sequence Phe19 Thr281, with C hIgG Fc Expression System HEK293 Molecular Weight 72 95kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g Physical Appearance Lyophilized Powder Storage Buffer PBS, 5% trehalose, PH7. 4 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid

Product Specification


Species Mouse
Synonyms CD30; CD30KI-1; CD30L receptor; D1S166EKi-1; TNFRSF8
Accession Q60846
Amino Acid Sequence Phe19-Thr281, with C-hIgG Fc
Expression System HEK293
Molecular Weight

72-95kDa (Reducing)

Purity >95% by SDS-PAGE
Endotoxin <0.1EU/μg
Physical Appearance Lyophilized Powder
Storage Buffer PBS, 5% trehalose, PH7.4
Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1. Oflzoglu E. et al. (2009) Adv. Exp. Med. Biol. 647:174
2. Kennedy, M.K. et al. (2006) Immunology 118:143.
3.Tarkowski, M. (2003) Curr. Opin. Hematol. 10:267.

Background

CD30, also known as Ki-1 antigen and TNFRSF8, is a 120 kDa type I transmembrane glycoprotein belonging to the TNF receptor superfamily. Mature mouse CD30 consists of a 264 amino acid (aa) extracellular domain (ECD) with three cysteine-rich repeats, a 27 aa transmembrane segment, and a 190 aa cytoplasmic domain. In contrast, human CD30 includes an additional 90 aa in the ECD and contains six cysteine-rich repeats. CD30 is normally expressed on antigen-stimulated Th cells and B cells. However, it is upregulated in Hodgkin’s disease (on Reed-Sternberg cells), other lymphomas, chronic inflammation, and autoimmunity. CD30 binds to CD30 Ligand/TNFSF8 which is expressed on activated Th cells, monocytes, granulocytes and medullary thymic epithelial cells. In B cells, CD30 ligation promotes cellular proliferation and antibody production in addition to the expression of CXCR4, CCL3,and CCL5. An 85 ‑ 90 kDa soluble form of CD30 is shed from the cell surface by TACE-mediated cleavage. Soluble CD30 retains the ability to bind CD30 Ligand and functions as an inhibitor of normal CD30 signaling.

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SKU: 50353089028

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Charlie
Lake Worth, US
★★★★★ 5
Interactive puppy fun
Color: Blue
Pups love this and I enjoy watching them have so much fun. Serious playtime followed by a well earned nap!
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Reviewed in the United States on May 4, 2026
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Nala Nose Best 🐾
Los Angeles, US
★★★★★ 3
Well-designed and quiet, but didn’t keep my dog interested
Color: Blue
My dog was interested in this at first, but she would lose interest after a few minutes and move on. I do like that it’s quieter than the hard plastic ball toys, and the charge lasts well. The internal charging port that twists closed is also a nice design feature. That said, it will occasionally turn on by itself, which can be a little surprising. Overall, it has some nice features, but it just didn’t keep my dog engaged.
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Reviewed in the United States on April 30, 2026
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Verified Purchase
OhCaptainMyCaptain
Phoenix, US
★★★★★ 1
Good - for a few hours
Color: Blue, Color: Blue
Concept is fantastic. Dog loved it. Problem is that she figured out how to open it within two hours of play. The robot core, alas, did not survive. In the photo, you see a tooth went cleanly into the button and that was the end of the toy.
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Reviewed in the United States on May 17, 2026
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laruex3
Bozeman, US
★★★★★ 5
The most engaging interactive toy for my Border Collie
Color: Orange, Color: Orange
My Border Collie is not a big ball player. He prefers tug type games and actually gives me a look like, “Are you stupid? I’m not going to keep bringing that to you if all you’re going to do is throw it away again!” after about the third time I throw a ball for him to fetch. However, I can only play tug so often and I need him to be entertained and engaged as much as possible. I got him a smaller, non-padded ball like this hoping he would like the interactive aspect of it. He did- he actually loved it! But it was loud, hard on his teeth, would come apart periodically, and he kept hitting the off button when playing with it. It drove me crazy. This one is so much better overall! The soft outer shell is not only easier on his teeth, but it is super resilient to biting and chewing. He actually likes to carry this thing around in his mouth while it’s bouncing and vibrating. The three modes give great flexibility for different kinds of play. His favorite is the most active mode: the ball reacts to touch and practically bounces itself across the floor when he touches it with his paw or mouth. I will point out that in one of the modes, I thought the battery wasn’t charged or there was a motor issue because it’s very subdued movement; however, it’s just set up as a low-key option. Be sure to check out each mode to see which works best for your dog at different times. I can’t say enough about this ball- I have been so pleasantly surprised by how much he loves it. The rechargeable feature is super convenient, it’s big enough to not get stuck under the couch, and it automatically shuts off based on whichever mode it’s set on. As the owner of a busy, super-smart dog who needs to be engaged in mental and physical activity, I think this all is worth every penny. In fact, I’m buying one for a friend who has a Border Collie pup with lots of energy to burn! I highly recommend this toy- it’s the most engaging toy I’ve found that Finn will play with on his own.
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Reviewed in the United States on April 13, 2026
D
Verified Purchase
Dani
Battle Creek, US
★★★★★ 2
Not as Smart or Interactive as You Think it Will Be
Color: Blue
This is an honest review from a schnauzer owner who has has wanted this cheerble ball for their dog for more than one year. I finally bougI finally bought this toy and both me and my dog are disappointed. The settings are...i would say dog friendly as I'd assumed a dog ball would be. What I mean by that is, for example: the calm play setting is muuch too calm. Super light puffs of energy, like a battery is dying. And the playful setting is scary, alarmingly so. The intervals in between are too long. The ball does not bounce. So they just have settings all wrong. The size is good for a large dog only. Do not buy if you have a small to medium dog. I even think the material is okay. I've only had it for a few days so I can't even speak to how the material holds up. Really hoping to love this ball for my dog. It was not the distraction I was hoping it would be so I could work from home while my dog had fun. I'm hoping this can help someone else who's been pining over it. Essentially, it's a $35-$50 well made weighted ball that moves occasionally.
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Reviewed in the United States on May 9, 2026

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