CD30/TNFRSF8 Fc Chimera Protein, Mouse
SKU: 41839580047

CD30/TNFRSF8 Fc Chimera Protein, Mouse

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Description

CD30/TNFRSF8 Fc Chimera Protein, MouseProduct Specification Species Mouse Synonyms CD30; CD30KI 1; CD30L receptor; D1S166EKi 1; TNFRSF8 Accession Q60846 Amino Acid Sequence Phe19 Thr281, with C hIgG Fc Expression System HEK293 Molecular Weight 72 95kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g Physical Appearance Lyophilized Powder Storage Buffer PBS, 5% trehalose, PH7. 4 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid

Product Specification


Species Mouse
Synonyms CD30; CD30KI-1; CD30L receptor; D1S166EKi-1; TNFRSF8
Accession Q60846
Amino Acid Sequence Phe19-Thr281, with C-hIgG Fc
Expression System HEK293
Molecular Weight

72-95kDa (Reducing)

Purity >95% by SDS-PAGE
Endotoxin <0.1EU/μg
Physical Appearance Lyophilized Powder
Storage Buffer PBS, 5% trehalose, PH7.4
Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1. Oflzoglu E. et al. (2009) Adv. Exp. Med. Biol. 647:174
2. Kennedy, M.K. et al. (2006) Immunology 118:143.
3.Tarkowski, M. (2003) Curr. Opin. Hematol. 10:267.

Background

CD30, also known as Ki-1 antigen and TNFRSF8, is a 120 kDa type I transmembrane glycoprotein belonging to the TNF receptor superfamily. Mature mouse CD30 consists of a 264 amino acid (aa) extracellular domain (ECD) with three cysteine-rich repeats, a 27 aa transmembrane segment, and a 190 aa cytoplasmic domain. In contrast, human CD30 includes an additional 90 aa in the ECD and contains six cysteine-rich repeats. CD30 is normally expressed on antigen-stimulated Th cells and B cells. However, it is upregulated in Hodgkin’s disease (on Reed-Sternberg cells), other lymphomas, chronic inflammation, and autoimmunity. CD30 binds to CD30 Ligand/TNFSF8 which is expressed on activated Th cells, monocytes, granulocytes and medullary thymic epithelial cells. In B cells, CD30 ligation promotes cellular proliferation and antibody production in addition to the expression of CXCR4, CCL3,and CCL5. An 85 ‑ 90 kDa soluble form of CD30 is shed from the cell surface by TACE-mediated cleavage. Soluble CD30 retains the ability to bind CD30 Ligand and functions as an inhibitor of normal CD30 signaling.

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SKU: 41839580047

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Valerie M
Birmingham, US
★★★★★ 5
Good read
Format: Paperback
My 8 year old son really enjoyed this graphic novel. Asked for the 2nd book but cant find it. Will keep looking.
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Reviewed in the United States on March 22, 2026
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Jrzshore
New York, US
★★★★★ 4
Cute, Well Done, Much Better Than I Presumed
Format: Paperback
I am not the target for this book. I'm a 48 year old man (wow, that hits harder when you type it...) But you know what? This is really good! It's a quick read, the whole story is VERY comic book superhero origin (which... I mean... it should be, that's what it is!) We have a young lady who is in the foster system, so needless to say she's always suspect of everyone and everything. When she finds a new set of foster parents, her curiosity about her foster mother gets the best of her. What she finds? Paints that give super powers! Wacky hijinks ensue.. until the military wants the paint back. Then it's less wacky. But it's adorable! The art is great for the material, the coloring is amazing, and the story is surprisingly cute. It's genuinely good! My 9-year old daughter, who IS the target audience, loved it too, and getting her to read anything is like pulling teeth, so if she likes it, it must be good!
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Reviewed in the United States on November 10, 2025
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Dana Dee
Draper, US
★★★★★ 5
Great book!
Format: Paperback
My daughter is 8 years old and loves reading graphic novels. I came across this one and wasn’t sure if it would be for her age but figured we would give it a try. So glad I ordered it! She read it so fast and it quickly became one of her favorites! I have the second book in my cart now.
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Reviewed in the United States on January 6, 2026
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colette fardella
Pawtucket, US
★★★★★ 5
great for 4th grade
Format: Paperback
my 4th grader loved this book, wish more were paperback
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Reviewed in the United States on March 2, 2026
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Anne Christofferson
Carnegie, US
★★★★★ 5
Good Artwork
Format: Paperback
This was a well drawn graphic novel
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Reviewed in the United States on March 4, 2026

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