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Description
MICB Recombinant Rabbit mAb (S-1472-102)Product Specification Host Rabbit Antigen MICB Synonyms MHC class I polypeptide related sequence B; MIC B; PERB11. 2 Immunogen Recombinant Protein Location Cell membrane, Endoplasmic reticulum Accession Q29980 1 Clone Number S 1472 102 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC Reactivity Hu Positive Sample T 47D, K562 Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer
Product Specification
| Host | Rabbit |
| Antigen | MICB |
| Synonyms | MHC class I polypeptide-related sequence B; MIC-B; PERB11.2 |
| Immunogen | Recombinant Protein |
| Location | Cell membrane, Endoplasmic reticulum |
| Accession | Q29980-1 |
| Clone Number | S-1472-102 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, ICC |
| Reactivity | Hu |
| Positive Sample | T-47D, K562 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| ICC | 1:500 | Hu |
Background
MICB (MHC class I polypeptide-related sequence B) is a stress-inducible, heavily glycosylated transmembrane protein encoded by the MICB gene located on chromosome 6p21.33. It functions as a ligand for the NKG2D receptor, which is expressed on natural killer (NK) cells, CD8+ T cells, and γδ T cells. Upon binding, MICB activates the cytolytic response of these immune cells, promoting their ability to target and eliminate stressed or transformed cells, such as tumor cells or virus-infected cells. Unlike classical MHC class I molecules, MICB does not associate with β-2-microglobulin or bind peptides. Its expression is induced by cellular stress, including DNA damage and viral infections, making it a crucial component in both innate and adaptive immune responses. MICB is widely expressed in various tissues, including lymph nodes and bone marrow, highlighting its role in diverse physiological contexts.
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