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Description
DR3/TNFRSF25 His&Fc Tag Protein, HumanProduct Specification Species Human Synonyms APO3; DDR3; DR3; TNFRSF12; WSL; WSL1; TNFRSF25; LARD; TR3; TRAMP; WSL LR Accession AAI17190 Amino Acid Sequence Gln25 Gln199 Expression System HEK293 Molecular Weight Predicted MW of 49. 80 kDa. Due to glycosylation, the protein migrates to 60 70 kDa based on Bis Tris PAGE result. Purity 95% by SDS PAGE Endotoxin <1EU g Conjugation Unconjugated Tag Human Fc Tag, His Tag Physical Appearance Liquid Storage
Product Specification
| Species | Human |
| Synonyms | APO3; DDR3; DR3; TNFRSF12; WSL; WSL1; TNFRSF25; LARD; TR3; TRAMP; WSL-LR |
| Accession | AAI17190 |
| Amino Acid Sequence | Gln25-Gln199 |
| Expression System | HEK293 |
| Molecular Weight |
Predicted MW of 49.80 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Bis-Tris PAGE result.
|
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Tag | Human Fc Tag, His Tag |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, pH 7.4 |
| Stability & Storage |
Valid for 12 months from date of receipt when stored at -80°C. |
Background
Death Receptor 3 (DR3), also known as TNFRSF25, TRAMP, LARD, or WSL-1, is a death-domain-containing TNF-family receptor that, like its closest paralog TNFR1, binds the adaptor molecule TRADD through its cytoplasmic death domain. TRADD recruitment endows DR3 with dual-signaling capability to activate NF−κB and MAP-kinase signaling or alternatively trigger caspase activation and programmed cell death.
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