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Description
GDNF Protein , MouseProduct Specification Species Mouse Synonyms GDNF; Glial Derived Neurotrophic Facto; ATF 1; ATF2; HFB1 GDNF; HSCR3 Accession P48540 Amino Acid Sequence Met77 Ile211 Expression System CHO Molecular Weight 17~22 kDa (Reducing) Purity > 95% by SDS PAGE & > 95% by HPLC Endotoxin <0. 2EU g Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized Powder Storage Buffer PBS Reconstitution It is recommended that this vial be briefly centrifuged
Product Specification
| Species | Mouse |
| Synonyms | GDNF; Glial-Derived Neurotrophic Facto; ATF-1; ATF2; HFB1-GDNF; HSCR3 |
| Accession | P48540 |
| Amino Acid Sequence |
Met77-Ile211
|
| Expression System | CHO |
| Molecular Weight |
17~22 kDa (Reducing) |
| Purity | > 95% by SDS-PAGE & > 95% by HPLC |
| Endotoxin | <0.2EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer |
PBS
|
| Reconstitution |
It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH₂O or PBS up to 100 μg/ml.
|
| Stability & Storage |
Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.
|
Background
Glial-Derived Neurotrophic Factor, also known as GDNF and ATF-1, is a neurotrophic factor belonging to the TGF-beta family. It is expressed in both central nervous system (CNS) and non-CNS tissues. GDNF signals through a receptor system composed of a RET and one of the four GFR alpha receptors. It promotes the survival and differentiation of dopaminergic neurons, and increases their highaffinity dopamine uptake. In a mouse Parkinson’s Disease model, GDNF has been shown to improve bradykinesia, rigidity, and postural instability. GDNF has also been shown to regulate kidney development, spermatogenesis and affect alcohol consumption.
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