MICB Recombinant Rabbit mAb (SDT-1472-102)
SKU: 15940061653

MICB Recombinant Rabbit mAb (SDT-1472-102)

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Description

MICB Recombinant Rabbit mAb (SDT-1472-102)Product Specification Host Rabbit Antigen MICB Synonyms MHC class I polypeptide related sequence B; MIC B; Immunogen Recombinant Protein Accession Q29980 1 Clone Number SDT 1472 102 Antibody Type Recombinant mAb Isotype IgG Application Sandwich ELISA Reactivity Hu Cross Reactivity No cross reactivity against MICB, NKG2D Purification Protein A Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4, 0. 03%

Product Specification


Host Rabbit
Antigen MICB
Synonyms MHC class I polypeptide-related sequence B; MIC-B;
Immunogen Recombinant Protein
Accession Q29980-1
Clone Number SDT-1472-102
Antibody Type Recombinant mAb
Isotype IgG
Application Sandwich ELISA
Reactivity Hu
Cross Reactivity

No cross-reactivity against MICB, NKG2D

Purification Protein A
Concentration 2 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS pH7.4, 0.03% Proclin 300

Stability & Storage

12 months from date of receipt, 2 to 8 °C as supplied

Background

MHC I polypeptide-related sequence B (MICB) is a highly glycosylated transmembrane protein encoded by the MICB gene, located on chromosome 6p21.33. It functions as a ligand for the NKG2D receptor, a type II receptor expressed on natural killer (NK) cells, CD8+ T cells, and γδ T cells. The binding of MICB to NKG2D activates cytolytic responses in these immune cells, promoting the elimination of stressed or infected cells. Unlike MHC class I molecules, MICB does not associate with β-2-microglobulin or bind peptides. MICB is stress-induced, meaning its expression increases under cellular stress conditions, such as DNA damage or viral infection. This protein is widely expressed in various tissues, including lymph nodes and bone marrow, highlighting its role in immune surveillance. The external domains of MICB are proteolytically cleaved by surface proteases and shed into the extracellular space. MICB shedding by cancer cells causes effective escape from NKG2D recognition and allows the development of cancers. Patients frequently have increased concentrations of soluble MICA/B molecules shed in the blood plasmas and sera, thus indicating that MICA/B shedding is a therapeutic target in immune-oncology.

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SKU: 15940061653

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Harmolu
Whiting, US
★★★★★ 5
Love the crazy giggle
Size: 12"
Entertaining toy for my husky but he's so rough and tough that he torn the cover off and manages to turn the giggle sound off. He really enjoys it still though.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 7, 2017
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Carol Paulsen
Birmingham, US
★★★★★ 4
My guy loves the duck. At first the "different" ...
Size: 12"
My guy loves the duck. At first the "different" sound put him off a bit but soon he was throwing his new toy all over the house. The reason I gave 4 stars is because my 8 lb. pup managed to undo the ducks braided legs and now they are nothing but a bunch of strings hanging from its body. Other than that he enjoys this toy immensely.
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Reviewed in the United States on November 21, 2015
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Monkey Stew
Whiting, US
★★★★★ 5
Great toy...
Size: 12"
My dog LOVES this toy! It's very durable as he loves to throw it around. It was bigger than I expected, but my little shih Tzu still loves it.
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Reviewed in the United States on December 29, 2016
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JM Cook
Boise, US
★★★★★ 5
Cute and well made, fun toy for dogs of all sizes.
Color: Frog (Green)
My small dogs luv this toy, especially the handle part for playing tug of war. My peekapoo is only 14 lbs. but he loves to get a grip on the handle with his mouth and tug really hard which also stretches the body and makes the crunchy noises! My chihuahua loves it too and she tries to grab the eyes with her mouth. It is a very well made toy with a squeaker and light stuffing in the head which makes me feel good about letting them play with it. It is strong and very cute and I think they will have it for a long time.
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Reviewed in the United States on May 29, 2026
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K. Zander
Omaha, US
★★★★★ 5
Octopus dog toy
My dogs love this toy! They love to play tug of war with it, using the rope legs. The legs will pull out if they are strong dogs! But if the dogs are having fun with it, it isn't a problem. One of my dogs has shredded some of the legs and put a hole in yhe body, but she is a strong chewer. There is a squeaker in the octopus body. They enjoy the toy, so I would recommend it.
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Reviewed in the United States on February 28, 2024

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